Why No Virus Has Ever Been Properly Isolated
The electron microscope problem.
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I surround, protect, purify and make harmless the following in-formation.
Preface
Unbekoming
Dec 03, 2025
Preface
This essay draws from Virus Mania: Corona/COVID-19, Measles, Swine Flu, Cervical Cancer and Other Viral Diseases—Why Vaccination, Profits, and Coercion Do Not Protect Us (3rd edition, 2021) by Torsten Engelbrecht, Claus Köhnlein, and Samantha Bailey. The book documents a fundamental problem in virology: the scientific standards established in the 1950s for virus identification were quietly abandoned in the 1960s when researchers couldn’t find the viruses they were looking for. What follows examines the evidence for this claim and its implications for modern virus detection methods.
Excerpts
The hypothesis that cancer might be caused by viruses was formulated in 1903, more than a century ago. It has never been convincingly demonstrated. Viral particles similar to those readily recognized in cancerous and leukemic mice have never been seen in human cancers. When this became clear in the late 1960s, the problem was declared to be with electron microscopy, not with the dogma of viral oncology.
Viruses that purportedly threaten to wipe out humanity—H5N1, SARS virus, SARS-CoV-2—have evidently never been seen by anyone in properly purified form. The procedure rarely gets carried out in modern viral research. Around 1960, before contemporary molecular biology arose, electron microscopy was held to be the best way of identifying viruses in cell cultures. Now it has been replaced by indirect methods that cannot prove what they claim to prove.
The PCR tests are explicitly labeled “Research Use Only (RUO), not for diagnostic purposes” in their user manuals, according to evidence brought to court in the Netherlands. The CDC and FDA admit the SARS-CoV-2 RT-PCR tests are not suitable for diagnosis of SARS-CoV-2 infection. The instructions for use of the PCR tests explicitly state they are not intended for what they are overwhelmingly used for: diagnosis.
Antibody tests, PCR viral load tests, and helper cell counts are surrogate markers—alternative methods by which doctors determine whether someone is infected with a virus. Instead of investigating whether real disease symptoms have occurred, doctors look at laboratory data. Often enough, surrogate markers have led to misdiagnosis.
Heinz Ludwig Sänger, professor of molecular biology and 1978 winner of the Robert Koch Prize, stated that “HIV has never been isolated, for which reason its nucleic acids cannot be used in PCR virus load tests as the standard for giving evidence of HIV.”
Kary Mullis, who received the 1993 Nobel Prize in Chemistry for the invention of PCR, stated: “The PCR test doesn’t tell you that you are sick. These tests cannot detect free, infectious viruses at all.”
The standard was established in the 1950s: purify the particles, image them with an electron microscope, biochemically characterize them. When researchers in the 1960s couldn’t find cancer viruses in human cells using this standard, they blamed the methodology rather than their hypothesis. They invented molecular markers to substitute for the absent viral particles. Modern virology inherited this substitution and built an entire edifice of virus detection on methods that cannot prove a virus exists without first isolating that virus.
No virus has ever been properly isolated according to the standards virologists themselves established in the 1950s. The electron microscope problem is not a problem with electron microscopes. It is a problem with what happens when evidence doesn’t support a hypothesis and researchers decide to change the evidence rather than the hypothesis. Resource and full essay at
https://unbekoming.substack.com/p/the-electron-microscope-problem-why
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Without prejudice and without recourse
Doreen Agostino
Our Greater Destiny Blog
virology